Granule Strength Determination and Compactibility of Granules of Varying Density

Purpose: As in-line process analytics are becoming more widely accepted, it is important to illustrate that a measurement of interest will provide the expected outcome if that control point has reached a desired level. This methodology is especially true for novel applications. The purpose of this work was to investigate the role of densification during high shear granulation and the resulting impact on the compaction properties of the prepared granules. Additionally, the structural dependence of granule strength on the compaction phase was investigated to establish the validity of controlling granule density during high-shear wet granulation to ensure reproducible compaction properties.